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CS-W001157 4
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4-Chloro-6-methyl-7-azaindole

  • CAS No. 171879-99-5

  • Cat. No. CS-B0503
  • Purity≥97%
  • MDL No.MFCD09880146

*For research and further manufacturing use only, not for direct human use.

4-Chloro-6-methyl-7-azaindole|CS-B0503

Structure of 171879-99-5

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General Information

  • CAS No. 171879-99-5
  • Cat. No. CS-B0503
  • Purity ≥97%
  • MDL No. MFCD09880146
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇ClN₂
  • Molecular Weight 166.61
  • Synonym(s) 4-Chloro-6-methyl-1h-pyrrolo[2,3-b]pyridine
  • SMILES ClC1=C2C(NC=C2)=NC(C)=C1

Description

4-Chloro-6-methyl-7-azaindole is a bench-stable, electron-deficient heterocycle featuring a chlorinated aryl moiety and a methyl-substituted pyridine ring. This structural motif enables efficient coupling in cross-coupling reactions and serves as a key scaffold in medicinal chemistry for targeted kinase inhibition and fluorescent probe development.

Application

4-Chloro-6-methyl-7-azaindole serves as a versatile building block in medicinal chemistry, enabling efficient construction of bioactive heterocycles. Its chlorine substituent facilitates palladium-catalyzed cross-coupling reactions, while the methyl group enhances metabolic stability. The 7-azaindole core provides favorable solubility and hydrogen-bonding capacity, making it valuable for scaffold diversity in drug discovery programs.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   28.68
  • LogP   2.52472
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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