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CS-W001157 4
Total: USD 88.00

2,6-Difluoronicotinic acid

  • CAS No. 171178-50-0

  • Cat. No. CS-0091204
  • Purity≥97%
  • MDL No.MFCD08064047

*For research and further manufacturing use only, not for direct human use.

2,6-Difluoronicotinic acid|CS-0091204

Structure of 171178-50-0

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General Information

  • CAS No. 171178-50-0
  • Cat. No. CS-0091204
  • Purity ≥97%
  • MDL No. MFCD08064047
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃F₂NO₂
  • Molecular Weight 159.09
  • Synonym(s) 3-Pyridinecarboxylicacid,2,6-difluoro-(9CI)
  • SMILES O=C(C1=CC=C(F)N=C1F)O

Description

2,6-Difluoronicotinic acid is a bench-stable, electron-deficient heterocyclic carboxylic acid featuring fluorine atoms at the 2- and 6-positions of the pyridine ring. This substitution pattern enhances metabolic stability and modulates electronic properties, enabling direct incorporation into pharmaceutical intermediates. The molecule pairs effectively with nucleophiles in coupling reactions and serves as a key scaffold for bioactive compound synthesis.

Synthesis

  • Route1
    • In-stock
      2,6-Difluoropyridine|CS-W013627
      1513-65-1
    • null|null
      124-38-9
    • ~95%
    • In-stock
      2,6-Difluoronicotinic acid|CS-0091204
      171178-50-0

    References

    • Schlosser, Manfred; Rausis, Thierry European Journal of Organic Chemistry, 2004 , # 5 p. 1018 - 1024
  • Route2

    References

    • Warner-Lambert Company Patent: US5654307 A1, 1997 ; US 5654307 A
  • Route3
    • null|null
      124-38-9
    • ~%
    • In-stock
      2,6-Difluoronicotinic acid|CS-0091204
      171178-50-0

    References

    • WO2006/100310 A1, ; Page/Page column 29 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.058
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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