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tert-Butyl 3-bromo-2-oxopiperidine-1-carboxylate

  • CAS No. 1707358-29-9

  • Cat. No. CS-0162687
  • Molecule weight278.14
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 3-bromo-2-oxopiperidine-1-carboxylate|CS-0162687

Structure of 1707358-29-9

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General Information

  • CAS No. 1707358-29-9
  • Cat. No. CS-0162687
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₆BrNO₃
  • Molecular Weight 278.14
  • Synonym(s) None
  • SMILES O=C(N1C(C(Br)CCC1)=O)OC(C)(C)C

Description

tert-Butyl 3-bromo-2-oxopiperidine-1-carboxylate features a brominated piperidinone scaffold with a bench-stable tert-butyl carbamate protecting group. This electrophilic building block enables direct functionalization at C3, facilitating efficient access to complex heterocycles in medicinal chemistry and peptide mimic synthesis under standard conditions.

Application

tert-Butyl 3-bromo-2-oxopiperidine-1-carboxylate serves as a versatile building block in medicinal chemistry, enabling the efficient construction of nitrogen-containing heterocycles. The bromide facilitates nucleophilic substitution, while the oxo group supports enolization and subsequent functionalization. Its bench-stable nature and compatibility with palladium-catalyzed cross-coupling reactions make it ideal for iterative synthesis of complex scaffolds in API development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   46.61
  • LogP   2.3074
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   0

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