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3-Chloro-6-(difluoromethyl)pyridazine

  • CAS No. 1706439-95-3

  • Cat. No. CS-0099192
  • Purity≥97%
  • MDL No.MFCD28013109

*For research and further manufacturing use only, not for direct human use.

3-Chloro-6-(difluoromethyl)pyridazine|CS-0099192

Structure of 1706439-95-3

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General Information

  • CAS No. 1706439-95-3
  • Cat. No. CS-0099192
  • Purity ≥97%
  • MDL No. MFCD28013109
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃ClF₂N₂
  • Molecular Weight 164.54
  • Synonym(s) 3-Chloro-6-difluoromethyl-pyridazine
  • SMILES FC(F)C1=NN=C(C=C1)Cl

Description

3-Chloro-6-(difluoromethyl)pyridazine is a fluorinated heterocyclic scaffold featuring a chloro substituent at the 3-position and a difluoromethyl group at the 6-position. This combination imparts enhanced metabolic stability and modulates electronic properties, enabling its use in medicinal chemistry for targeted kinase inhibition and as a building block in agrochemical development.

Application

3-Chloro-6-(difluoromethyl)pyridazine serves as a versatile building block in medicinal chemistry, enabling efficient access to fluorinated heterocyclic scaffolds. The difluoromethyl group imparts enhanced metabolic stability and modulates electronic properties, while the chloro substituent facilitates palladium-catalyzed cross-coupling reactions. Its bench-stable nature and compatibility with diverse functional groups support streamlined synthesis of complex API candidates.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   25.78
  • LogP   2.0676
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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