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5-Bromo-2-(hydroxymethyl)phenol

  • CAS No. 170434-11-4

  • Cat. No. CS-0097805
  • Purity≥96%
  • MDL No.MFCD08445665

*For research and further manufacturing use only, not for direct human use.

5-Bromo-2-(hydroxymethyl)phenol|CS-0097805

Structure of 170434-11-4

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General Information

  • CAS No. 170434-11-4
  • Cat. No. CS-0097805
  • Purity ≥96%
  • MDL No. MFCD08445665
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇BrO₂
  • Molecular Weight 203.03
  • Synonym(s) 5-Bromo-2-(hydroxymethyl)
  • SMILES OC1=CC(Br)=CC=C1CO

Description

5-Bromo-2-(hydroxymethyl)phenol features a bromine substituent at the meta position relative to a hydroxymethyl group, delivering enhanced reactivity for C–C coupling and functionalization. This electron-deficient phenolic scaffold enables selective derivatization under mild conditions, serving as a robust building block in synthetic organic chemistry and medicinal research.

Application

5-Bromo-2-(hydroxymethyl)phenol serves as a versatile building block for functionalized aromatic scaffolds, enabling direct incorporation into pharmaceutical and agrochemical intermediates. The hydroxymethyl group facilitates oxidation to aldehyde or carboxylic acid derivatives, while the bromine supports palladium-catalyzed cross-coupling reactions. Its bench-stable nature and compatibility with common protecting group strategies simplify downstream transformations in complex molecule synthesis.

Synthesis

  • Route1

    References

    • WO2009/97567 A1, ; Page/Page column 59 ; WO 2009/097567 A1
  • Route2
    • null|null
      50-00-0
    • null|null
      591-20-8
    • ~91%
    • In-stock
      5-Bromo-2-(hydroxymethyl)phenol|CS-0097805
      170434-11-4

    References

    • Organic and Biomolecular Chemistry, , vol. 12, # 19 p. 3100 - 3107

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   40.46
  • LogP   1.647
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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