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CS-W001157 4
Total: USD 88.00

Exatecan mesylate

  • CAS No. 169869-90-3

  • Cat. No. CS-2952
  • Purity≥98%
  • MDL No.MFCD04113012

*For research and further manufacturing use only, not for direct human use.

Exatecan mesylate|CS-2952

Structure of 169869-90-3

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General Information

  • CAS No. 169869-90-3
  • Cat. No. CS-2952
  • Purity ≥98%
  • MDL No. MFCD04113012
  • Storage 4°C, sealed storage, away from moisture and light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₅H₂₆FN₃O₇S
  • Molecular Weight 531.55
  • Synonym(s) DX8951f
  • SMILES O=S(C)(O)=O.O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=C5C6=C(CC[C@@H]5N)C(C)=C(F)C=C6N=C4C3=C2)=O

Description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.Phenoxyethanol USP reference standard for use in specified quality tests and assays.Also used to prepare standard stock solution for impurity analysis by Gas Chromatography in conjunction with Flame ionization detector in Phenoxyethanol according to United States Pharmacopeia (USP) monograph.

Application

Exatecan (mesylate) is a potent topoisomerase I inhibitor that serves as a key cytotoxic agent in the development of antibody-drug conjugates. Its stable, crystalline mesylate salt form enhances solubility and handling for preclinical studies. The molecule features a complex indole-based scaffold with high functional group tolerance, enabling site-specific conjugation via reactive linkers. It functions effectively in both solution-phase and solid-phase synthesis workflows, offering predictable reactivity and consistent performance in targeted cancer therapeutics research.

Safety Information

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GHS Pictogram :
GHS No : GHS08,GHS09
Signal Word : Danger
UN#: 3077
Class : 9
Packing Group : Ⅲ
Hazard Statements : H340-H360-H400-H410
Precautionary Statements : P201-P202-P273-P280-P308+P313-P391-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   161.81
  • LogP   1.97712
  • H_Acceptors   9
  • H_Donors   3
  • Rotatable_Bonds   1

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