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CS-W001157 4
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Tos-PEG4-CH2-Boc

  • CAS No. 169751-73-9

  • Cat. No. CS-0024789
  • Purity≥98%
  • MDL No.MFCD27977499

*For research and further manufacturing use only, not for direct human use.

Tos-PEG4-CH2-Boc|CS-0024789

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General Information

  • CAS No. 169751-73-9
  • Cat. No. CS-0024789
  • Purity ≥98%
  • MDL No. MFCD27977499
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₁H₃₄O₉S
  • Molecular Weight 462.55
  • Synonym(s) None
  • SMILES O=C(OC(C)(C)C)COCCOCCOCCOCCOS(C1=CC=C(C)C=C1)(=O)=O

Description

Tos-PEG4-CH2-Boc features a hydrophilic PEG4 spacer flanked by a tosyl (Tos) group and a Boc-protected amine, enabling orthogonal functionalization. This bifunctional reagent facilitates selective conjugation in aqueous environments while maintaining stability under standard bench conditions.

Application

Tos-PEG4-CH2-Boc serves as a versatile bifunctional building block for peptide and oligonucleotide synthesis, enabling efficient conjugation strategies. The tosyl (Tos) group provides a reliable leaving group for nucleophilic substitution, while the PEG4 spacer offers enhanced solubility and reduced aggregation. The CH2-Boc moiety allows for mild acid-labile deprotection, facilitating sequential functionalization. This compound exhibits excellent bench stability, compatibility with diverse reaction conditions, and straightforward purification by standard chromatographic methods.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   106.59
  • LogP   2.10842
  • H_Acceptors   9
  • H_Donors   0
  • Rotatable_Bonds   16

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