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CS-W001157 4
Total: USD 88.00

Methyl 1-methylpiperidine-2-carboxylate

  • CAS No. 1690-74-0

  • Cat. No. CS-0375594
  • Molecule weight157.21
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Methyl 1-methylpiperidine-2-carboxylate|CS-0375594

Structure of 1690-74-0

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General Information

  • CAS No. 1690-74-0
  • Cat. No. CS-0375594
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₅NO₂
  • Molecular Weight 157.21
  • Synonym(s) 1-methyl-piperidine-2-carboxylicacidmethylester
  • SMILES O=C(C1N(CCCC1)C)OC

Description

Methyl 1-methylpiperidine-2-carboxylate is a sterically hindered, bench-stable piperidine derivative featuring a methyl ester group at the C2 position. This configuration enhances solubility in common organic solvents and facilitates straightforward functionalization in synthetic transformations. The molecule serves as a key intermediate in the construction of bioactive alkaloids and pharmaceutical scaffolds due to its compatibility with diverse coupling and reduction protocols.

Application

Methyl 1-methylpiperidine-2-carboxylate serves as a versatile chiral building block in synthetic organic chemistry, enabling efficient access to piperidine-containing scaffolds. Its methyl ester functionality facilitates subsequent derivatization, while the N-methylpiperidine core provides favorable solubility and stability. The compound exhibits excellent functional group tolerance and is compatible with standard coupling, reduction, and alkylation protocols, making it a practical choice for medicinal chemistry and process development workflows.

Synthesis

  • Route1
    • null|null
      39160-67-3
    • ~94%
    • In-stock
      Methyl 1-methylpiperidine-2-carboxylate|CS-0375594
      1690-74-0

    References

    • Gomez, Elena; Miguel, Miriam; Jimenez, Oscar; De La Rosa, Guillermo; Lavilla, Rodolfo Tetrahedron Letters, 2005 , vol. 46, # 20 p. 3513 - 3516
  • Route2
    • null|null
      124685-63-8
    • ~89%
    • In-stock
      Methyl 1-methylpiperidine-2-carboxylate|CS-0375594
      1690-74-0
    • null|null
      199620-14-9

    References

    • Hegedus, Louis S.; Schwindt, Mark A.; De Lombaert, Stephane; Imwinkelried, Rene Journal of the American Chemical Society, 1990 , vol. 112, # 6 p. 2264 - 2273
  • Route3
    • null|null
      67-56-1
    • null|null
      201230-82-2
    • ~90%
    • In-stock
      Methyl 1-methylpiperidine-2-carboxylate|CS-0375594
      1690-74-0

    References

    • Hegedus, Louis S.; Schwindt, Mark A.; De Lombaert, Stephane; Imwinkelried, Rene Journal of the American Chemical Society, 1990 , vol. 112, # 6 p. 2264 - 2273

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   29.54
  • LogP   0.6437
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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