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(1S)-6-Methoxy-2,3-dihydro-1H-inden-1-amine

  • CAS No. 168903-23-9

  • Cat. No. CS-0055353
  • Purity≥97%
  • MDL No.MFCD06762392

*For research and further manufacturing use only, not for direct human use.

(1S)-6-Methoxy-2,3-dihydro-1H-inden-1-amine|CS-0055353

Structure of 168903-23-9

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General Information

  • CAS No. 168903-23-9
  • Cat. No. CS-0055353
  • Purity ≥97%
  • MDL No. MFCD06762392
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₃NO
  • Molecular Weight 163.22
  • Synonym(s) 1H-Inden-1-amine, 2,3-dihydro-6-methoxy-, (S)- (9CI)
  • SMILES N[C@H]1CCC2=C1C=C(OC)C=C2

Description

(1S)-6-Methoxy-2,3-dihydro-1H-inden-1-amine is a chiral amine scaffold featuring a stereodefined indane core with a methoxy group at the 6-position. This bench-stable, moisture-tolerant building block integrates readily into asymmetric synthesis, enabling efficient access to complex nitrogen-containing architectures through functionalization at the amine and aromatic sites.

Application

(1S)-6-Methoxy-2,3-dihydro-1H-inden-1-amine serves as a chiral building block for asymmetric synthesis, offering a rigid, enantiomerically pure scaffold with orthogonal functionality. The amine group facilitates facile derivatization, while the methoxy substituent enhances solubility and modulates electronic properties. Its bench-stable nature and compatibility with standard coupling and reduction protocols make it well-suited for medicinal chemistry campaigns involving indoline-based pharmacophores.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   35.25
  • LogP   1.6412
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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