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Structure of 168828-70-4
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4-(2-Fluoro-4-nitrophenyl)thiomorpholine features a fluorinated nitroaryl moiety integrated into a saturated heterocyclic thiomorpholine scaffold. This combination delivers enhanced reactivity in cross-coupling processes, with the electron-deficient aryl group enabling efficient palladium-mediated transformations. The molecule exhibits bench-stable handling characteristics and improved solubility in common organic solvents, facilitating use in synthetic workflows.
4-(2-Fluoro-4-nitrophenyl)thiomorpholine serves as a versatile building block in medicinal chemistry, enabling efficient construction of biologically active heterocycles. Its electron-deficient aryl moiety facilitates nucleophilic aromatic substitution and transition-metal-catalyzed coupling reactions. The thiomorpholine scaffold offers favorable solubility and metabolic stability, while the fluorine and nitro groups enhance target binding affinity and modulate electronic properties. This compound exhibits bench stability and compatibility with standard purification protocols, making it well-suited for iterative synthesis campaigns in API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: