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Tert-butyl n-[1-(hydroxymethyl)cyclopentyl]carbamate

  • CAS No. 168540-07-6

  • Cat. No. CS-0262367
  • Purity≥98%
  • MDL No.MFCD04038539

*For research and further manufacturing use only, not for direct human use.

Tert-butyl n-[1-(hydroxymethyl)cyclopentyl]carbamate|CS-0262367

Structure of 168540-07-6

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General Information

  • CAS No. 168540-07-6
  • Cat. No. CS-0262367
  • Purity ≥98%
  • MDL No. MFCD04038539
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₂₁NO₃
  • Molecular Weight 215.29
  • Synonym(s) tert-butyl [1-(hydroxymethyl)cyclopentyl]carbamate
  • SMILES O=C(OC(C)(C)C)NC1(CO)CCCC1

Description

Tert-butyl n-[1-(hydroxymethyl)cyclopentyl]carbamate is a bench-stable, moisture-tolerant carbamate protecting group designed for selective amino functionality modulation. This cyclopentyl-based derivative features a hydroxymethyl handle that enables downstream functionalization via oxidation or coupling reactions. The tert-butyl moiety ensures easy removal under mild acidic conditions, facilitating clean deprotection without affecting sensitive functionalities.

Application

Tert-butyl N-[1-(hydroxymethyl)cyclopentyl]carbamate serves as a versatile building block in medicinal chemistry, enabling the introduction of a cyclopentyl-substituted hydroxymethyl moiety with high functional group tolerance. The tert-butyl carbamate (Boc) group provides excellent bench stability and facilitates straightforward deprotection under mild acidic conditions. This compound functions effectively in coupling reactions and serves as a key intermediate for constructing bioactive heterocyclic scaffolds and polar pharmacophores.

Safety Information

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GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 3077
Class : 9
Packing Group : Ⅲ
Hazard Statements : H301-H311-H331
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361+P364-P405-P501

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Computational Chemistry Data

  • TPSA   58.56
  • LogP   1.8162
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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