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CS-W001157 4
Total: USD 88.00

1-Hydroxycyclopentanecarboxylic acid

  • CAS No. 16841-19-3

  • Cat. No. CS-W006221
  • Purity≥96%
  • MDL No.MFCD00045414

*For research and further manufacturing use only, not for direct human use.

1-Hydroxycyclopentanecarboxylic acid|CS-W006221

Structure of 16841-19-3

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General Information

  • CAS No. 16841-19-3
  • Cat. No. CS-W006221
  • Purity ≥96%
  • MDL No. MFCD00045414
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₀O₃
  • Molecular Weight 130.14
  • Synonym(s) NSC 64918
  • SMILES OC(=O)C1(O)CCCC1

Description

1-Hydroxycyclopentanecarboxylic acid features a cyclopentane ring bearing both hydroxyl and carboxylic acid functional groups in close proximity, enabling versatile conjugation in synthetic pathways. This bifunctional scaffold supports efficient derivatization for bioconjugation, polymer synthesis, and medicinal chemistry applications under standard conditions.

Application

1-Hydroxycyclopentanecarboxylic acid serves as a versatile building block in synthetic organic chemistry, enabling efficient access to functionalized cyclopentane scaffolds. Its carboxylic acid and hydroxyl groups provide orthogonal handles for derivatization, facilitating esterification, amidation, or protection strategies. The molecule exhibits good bench stability and is compatible with standard purification methods, supporting its use in iterative synthesis and the construction of complex heterocyclic systems relevant to medicinal chemistry applications.

Synthesis

  • Route1
    • 1-[(trimethylsilyl)oxy]cyclopentane-1-carbonitrile|CS-0237125
      25438-35-1
    • ~93%
    • In-stock
      1-Hydroxycyclopentanecarboxylic acid|CS-W006221
      16841-19-3

    References

    • ARDELYX, INC.; LEWIS, Jason, G.; REICH, Nicholas; CHEN, Tao; JACOBS, Jeffrey W.; CHARMOT, Dominique; NAVRE, Marc; FINN, Patricia; CARRERAS, Christopher; SPENCER, Andrew Patent: WO2013/96771 A1, 2013 ; Location in patent: Page/Page column 100 ;
  • Route2

    References

    • Roussis, Vassilios; Gloer, Katherine B.; Wiemer, David F. Journal of Organic Chemistry, 1988 , vol. 53, # 9 p. 2011 - 2015
  • Route3
    • null|null
      120-92-3
    • ~%
    • In-stock
      1-Hydroxycyclopentanecarboxylic acid|CS-W006221
      16841-19-3

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 17 p. 4837 - 4840

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301
Precautionary Statements : P264-P270-P330-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   57.53
  • LogP   0.3761
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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