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CS-W001157 4
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4-Chloropyridazin-3-ol

  • CAS No. 1677-79-8

  • Cat. No. CS-W019136
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-Chloropyridazin-3-ol|CS-W019136

Structure of 1677-79-8

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General Information

  • CAS No. 1677-79-8
  • Cat. No. CS-W019136
  • Purity ≥95%
  • MDL No. None
  • Storage -20°C, stored under nitrogen, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₃ClN₂O
  • Molecular Weight 130.53
  • Synonym(s) 5-chloro-1H-pyridazin-6-one
  • SMILES OC1=NN=CC=C1Cl

Description

4-Chloropyridazin-3-ol is a bench-stable heterocyclic building block featuring a chlorine atom at the 4-position and a hydroxyl group at the 3-position. This combination imparts enhanced reactivity for nucleophilic substitution and facilitates integration into bioactive scaffolds. The electron-deficient pyridazinone core supports conjugation in pharmaceutical intermediates, enabling efficient coupling reactions under mild conditions.

Application

4-Chloropyridazin-3-ol serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the C4 position via nucleophilic substitution. Its stability under standard reaction conditions and compatibility with diverse coupling partners facilitate efficient access to substituted pyridazinones. The hydroxyl group provides a handle for derivatization, while the chloro substituent offers orthogonal reactivity, making it valuable for constructing heterocyclic scaffolds in API development.

Synthesis

  • Route1
    • 4-Chloro-5-hydrazinyl-2,3-dihydropyridazin-3-one|CS-0234642
      6959-56-4
    • ~%
    • In-stock
      4-Chloropyridazin-3-ol|CS-W019136
      1677-79-8

    References

    • Li, Jim; Fidalgo, Javier de Vincente; Schoenfield, Ryan Craig; Talamas, Francisco Xavier Patent: US2011/70189 A1, 2011 ; Location in patent: Page/Page column 19-20 ;
  • Route2
    • null|null
      1314898-43-5
    • ~%
    • In-stock
      4-Chloropyridazin-3-ol|CS-W019136
      1677-79-8

    References

    • Chin, Elbert; Li, Jim; Lui, Albert Sui-Ting; Talamas, Francisco Xavier Patent: US2010/297073 A1, 2010 ; Location in patent: Page/Page column 26 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   46.01
  • LogP   0.8356
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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