tert-Butyl 5-fluorospiro[indoline-3,4'-piperidine]-1'-carboxylate

Name: tert-Butyl 5-fluorospiro[indoline-3,4'-piperidine]-1'-carboxylate
Brand: ChemScene
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CAS No. 167484-91-5
Cat. No. CS-0047230
Purity≥95%
MDL No.None

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tert-Butyl 5-fluorospiro[indoline-3,4'-piperidine]-1'-carboxylate|CS-0047230

Structure of 167484-91-5

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Description

tert-Butyl 5-fluorospiro[indoline-3,4'-piperidine]-1'-carboxylate features a rigid spirocyclic scaffold integrating an electron-deficient indoline and a piperidine ring, enabling precise spatial control in medicinal chemistry. The tert-butyl ester group offers bench-stable protection for amine functionalization, while the fluorine atom enhances metabolic stability and modulates electronic properties. This compound serves as a key building block for targeted synthesis of bioactive molecules.

Application

tert-Butyl 5-fluorospiro[indoline-3,4'-piperidine]-1'-carboxylate serves as a versatile spirocyclic building block for the construction of fluorinated indoline-piperidine scaffolds prevalent in medicinal chemistry. The tert-butyl carbamate group enables straightforward deprotection under mild acidic conditions, while the 5-fluoro substituent provides enhanced metabolic stability and modulates electronic properties. Its spiro architecture offers rigidity and defined stereochemistry, facilitating efficient access to complex heterocycles via standard functionalization protocols.

General Information

CAS No. 167484-91-5
Cat. No. CS-0047230
Purity ≥95%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₇H₂₃FN₂O₂
Molecular Weight 306.38
Synonym(s) tert-butyl 5-fluorospiro[indoline-3,4'
SMILES O=C(N1CCC2(C3=CC(F)=CC=C3NC2)CC1)OC(C)(C)C

Computational Chemistry Data

TPSA 41.57
LogP 3.5199
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aromatic heterocycle compounds Indolin compounds

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Building Blocks Skeleton Spirol Rings compounds

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tert-Butyl 5-fluorospiro[indoline-3,4'-piperidine]-1'-carboxylate

CAS No. 167484-91-5

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