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CS-W001157 4
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Fmoc-N-(2,4,6-trimethoxybenzyl)-glycine

  • CAS No. 166881-43-2

  • Cat. No. CS-0150478
  • Purity≥97%
  • MDL No.MFCD09952622

*For research and further manufacturing use only, not for direct human use.

Fmoc-N-(2,4,6-trimethoxybenzyl)-glycine|CS-0150478

Structure of 166881-43-2

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General Information

  • CAS No. 166881-43-2
  • Cat. No. CS-0150478
  • Purity ≥97%
  • MDL No. MFCD09952622
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₇H₂₇NO₇
  • Molecular Weight 477.51
  • Synonym(s) N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-[(2,4,6-trimethoxyphenyl)methyl]glycine
  • SMILES COC1=CC(=C(CN(CC(=O)O)C(=O)OCC2C3=CC=CC=C3C4=CC=CC=C42)C(=C1)OC)OC

Application

Fmoc-N-(2,4,6-trimethoxybenzyl)-glycine serves as a robust amino acid building block for peptide synthesis, combining the orthogonal protection of the Fmoc group with the sterically hindered, electron-rich 2,4,6-trimethoxybenzyl moiety. This dual protection system enables reliable N-terminal control in solid-phase and solution-phase workflows, offering enhanced stability against premature deprotection and compatibility with standard coupling conditions. The trimethoxybenzyl group facilitates efficient removal under mild acidic conditions, enabling high-purity product isolation.

Safety Information

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GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H315-H319-H335-H413
Precautionary Statements : P261-P264-P270-P271-P273-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   94.53
  • LogP   4.5481
  • H_Acceptors   6
  • H_Donors   1
  • Rotatable_Bonds   9

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