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CS-W001157 4
Total: USD 88.00

2-Methoxy-4-(trifluoromethoxy)phenol

  • CAS No. 166312-49-8

  • Cat. No. CS-0101200
  • Purity≥98%
  • MDL No.MFCD18397418

*For research and further manufacturing use only, not for direct human use.

2-Methoxy-4-(trifluoromethoxy)phenol|CS-0101200

Structure of 166312-49-8

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General Information

  • CAS No. 166312-49-8
  • Cat. No. CS-0101200
  • Purity ≥98%
  • MDL No. MFCD18397418
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇F₃O₃
  • Molecular Weight 208.13
  • Synonym(s) 2-methoxy-4-(trifluoromethyloxy)phenol
  • SMILES OC1=CC=C(C=C1OC)OC(F)(F)F

Description

2-Methoxy-4-(trifluoromethoxy)phenol features a phenolic hydroxyl group flanked by electron-withdrawing trifluoromethoxy and electron-donating methoxy substituents, creating a uniquely polarized aromatic system. This structural arrangement enhances its utility in synthetic routes requiring controlled reactivity, particularly in the development of bioactive molecules and advanced materials.

Application

2-Methoxy-4-(trifluoromethoxy)phenol serves as a valuable building block in the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its ortho-methoxy and para-trifluoromethoxy substituents confer enhanced metabolic stability and lipophilicity, while the phenolic hydroxyl group enables facile derivatization via etherification, esterification, or coupling reactions. The compound exhibits good bench stability and is compatible with standard synthetic protocols, facilitating its use in medicinal chemistry campaigns targeting CNS agents and kinase inhibitors.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.69
  • LogP   2.2994
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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