6-Chloroimidazo[1,2-b]pyridazin-3-amine

Name: 6-Chloroimidazo[1,2-b]pyridazin-3-amine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 166176-45-0
Cat. No. CS-W003682
Purity≥95%
MDL No.MFCD09881451

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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6-Chloroimidazo[1,2-b]pyridazin-3-amine|CS-W003682

Structure of 166176-45-0

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General Information

CAS No. 166176-45-0
Cat. No. CS-W003682
Purity ≥95%
MDL No. MFCD09881451
Storage -20°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₅ClN₄
Molecular Weight 168.58
Synonym(s) 6-CHLORO-IMIDAZO[1,2-B]PYRIDAZIN-3-AMINE, Fandachem
SMILES Clc1ccc2n(n1)c(N)cn2

Description

6-Chloroimidazo[1,2-b]pyridazin-3-amine features a fused heterocyclic core with a chlorine substituent at the 6-position, enabling enhanced electron-withdrawing character and improved metabolic stability. This scaffold integrates readily into kinase inhibitor libraries and serves as a key building block for bioactive compounds in medicinal chemistry.

Application

6-Chloroimidazo[1,2-b]pyridazin-3-amine serves as a versatile heterocyclic building block for medicinal chemistry and catalytic synthesis. Its chloro group enables palladium-catalyzed cross-coupling reactions, while the imidazopyridazin core provides structural rigidity and hydrogen-bonding capacity. The compound exhibits bench stability, facilitates purification via standard chromatography, and functions effectively in diversification campaigns targeting kinase inhibitors and CNS-active scaffolds.

Synthesis

Route1
- In-stock
  
  18087-76-8
- ~69%
- In-stock
  
  166176-45-0
References
- Kuwahara, Masaaki; Kawano, Yasuhiko; Shimazu, Hiroshi; Ashida, Yasuko; Miyake, Akio Chemical and Pharmaceutical Bulletin, 1996 , vol. 44, # 1 p. 122 - 131
Route2
- In-stock
  
  6775-78-6
- ~%
- In-stock
  
  166176-45-0
References
- Chemical and Pharmaceutical Bulletin, , vol. 44, # 1 p. 122 - 131

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 56.21
LogP 0.9649
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Imidazole compounds

Building Blocks Skeleton Aromatic heterocycle compounds Pyridazine compounds

Key Words

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6-Chloroimidazo[1,2-b]pyridazin-3-amine

CAS No. 166176-45-0

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