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CS-W001157 4
Total: USD 88.00

DC-Chol hydrochloride

  • CAS No. 166023-21-8

  • Cat. No. CS-0136740
  • Purity≥98%
  • MDL No.MFCD28143568

*For research and further manufacturing use only, not for direct human use.

DC-Chol hydrochloride|CS-0136740

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General Information

  • CAS No. 166023-21-8
  • Cat. No. CS-0136740
  • Purity ≥98%
  • MDL No. MFCD28143568
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃₂H₅₇ClN₂O₂
  • Molecular Weight 537.26
  • Synonym(s) DC-Cholesterol (hydrochloride)
  • SMILES CC(C)CCC[C@@H](C)[C@H]1CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](OC(NCCN(C)C)=O)CC[C@]4(C)[C@@]3([H])CC[C@]12C.[H]Cl

Description

Intercalating into lipid bilayers, DC-Cholesterol HCl (CAS 166023-21-8) enhances cationic liposome-mediated nucleic acid delivery efficiency in mammalian cell transfection assays.

Application

DC-Cholesterol HCl (CAS 166023-21-8) forms stable, cationic liposomes with L-α-phosphatidylethanolamine, dioleoyl, enabling efficient cytoplasmic delivery of nucleic acids across diverse mammalian cell lines through enhanced membrane fusion and endosomal escape. This setup streamlines gene delivery. Researchers leverage this for high-transfection efficiency in hard-to-transfect primary cells and stem cell systems.

Safety Information

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GHS Pictogram : N/A
GHS No : N/A
Signal Word : N/A
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H413
Precautionary Statements : P273-P501

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Computational Chemistry Data

  • TPSA   41.57
  • LogP   8.106
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   9

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