Mc-Val-Cit-PAB-Cl

Name: Mc-Val-Cit-PAB-Cl
Brand: ChemScene
Availability: InStock
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CAS No. 1639351-92-0
Cat. No. CS-0043347
Purity≥95%
MDL No.MFCD32201033

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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Structure of 1639351-92-0

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General Information

CAS No. 1639351-92-0
Cat. No. CS-0043347
Purity ≥95%
MDL No. MFCD32201033
Storage -20°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₈H₃₉ClN₆O₆
Molecular Weight 591.10
Synonym(s) None
SMILES O=C(N1CCCCCC(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC2=CC=C(CCl)C=C2)=O)=O)=O)C=CC1=O

Description

Mc-Val-Cit-PAB-Cl features a cleavable linker system designed for antibody-drug conjugates, combining a valine-citrulline dipeptide with a para-aminobenzyl carbamate (PAB) spacer. This structure enables efficient intracellular release of payload upon enzymatic cleavage in lysosomal environments, enhancing therapeutic efficacy and selectivity in targeted cancer therapies.

Application

Mc-Val-Cit-PAB-Cl serves as a well-established linker for antibody-drug conjugates, enabling site-specific payload attachment via amine-reactive acylation. The chloroacetamide moiety provides reliable conjugation to lysine residues or N-termini under mild conditions, while the Val-Cit dipeptide spacer offers proteolytic cleavage in target cells. This structure combines bench stability, predictable bioconjugation efficiency, and proven utility in generating homogenous ADCs with controlled drug-to-antibody ratios.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 179.8
LogP 1.9234
H_Acceptors 6
H_Donors 5
Rotatable_Bonds 17

Other Classifications

Life Science Linker Cleavable Linkers

Life Science Linker Maleimide Linkers

Life Science ADC Related Compound Cleavable Linker

Life Science ADC Related Compound Peptide/Protease Linker

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Enzyme Cleavable Linkers (Cleave Motif)

Chemical Biology PEGylation PEG Oligomers

Biochemistry Biochemicals and Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Biochemistry Biochemicals and Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Enzyme Cleavable Linkers (Cleave Motif)

Biochemistry Biochemicals and Reagents Bioconjugation Enzyme Cleavable Linkers (Cleave Motif)

Biochemistry Biochemicals and Reagents Bioconjugation PEGylation Reagents and PEG Spacers

Biochemistry Pharmaceutical Development and Drug Discovery Research Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Biochemistry Pharmaceutical Development and Drug Discovery Research Antibody-Drug Conjugates (ADC) Preparation Research Reagents Enzyme Cleavable Linkers (Cleave Motif)

Key Words

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Mc-Val-Cit-PAB-Cl

CAS No. 1639351-92-0

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