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6-Methoxy-2-azaspiro[3.3]heptane hydrochloride

  • CAS No. 1638761-19-9

  • Cat. No. CS-0050180
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

6-Methoxy-2-azaspiro[3.3]heptane hydrochloride|CS-0050180

Structure of 1638761-19-9

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General Information

  • CAS No. 1638761-19-9
  • Cat. No. CS-0050180
  • Purity ≥95%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₄ClNO
  • Molecular Weight 163.65
  • Synonym(s) None
  • SMILES Cl.COC1CC2(CNC2)C1

Description

6-Methoxy-2-azaspiro[3.3]heptane hydrochloride is a bench-stable, moisture-tolerant heterocyclic scaffold featuring a spirocyclic architecture with a tertiary amine and a methoxy substituent. This configuration enhances solubility and metabolic stability, enabling efficient incorporation into bioactive molecule design. The hydrochloride salt improves handling and crystallinity for synthetic workflows.

Application

6-Methoxy-2-azaspiro[3.3]heptane hydrochloride serves as a rigid, conformationally constrained scaffold for medicinal chemistry applications. Its spirocyclic core provides enhanced metabolic stability and defined spatial orientation of substituents. The tertiary amine functionality enables salt formation for improved solubility and crystallinity, while the methoxy group offers moderate electron donation and compatibility with standard synthetic transformations. This compound facilitates the construction of complex heterocyclic architectures and functions as a versatile building block in lead optimization campaigns.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   21.26
  • LogP   0.8066
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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