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CS-W001157 4
Total: USD 88.00

4-Bromo-5-methyl-1H-pyrrolo[2,3-b]pyridine

  • CAS No. 1638761-16-6

  • Cat. No. CS-0050980
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-Bromo-5-methyl-1H-pyrrolo[2,3-b]pyridine|CS-0050980

Structure of 1638761-16-6

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General Information

  • CAS No. 1638761-16-6
  • Cat. No. CS-0050980
  • Purity ≥96%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇BrN₂
  • Molecular Weight 211.06
  • Synonym(s) None
  • SMILES CC1=C(Br)C2=C(NC=C2)N=C1

Description

4-Bromo-5-methyl-1H-pyrrolo[2,3-b]pyridine features a fused heterocyclic core with bromine and methyl substituents enabling direct functionalization in cross-coupling reactions. This bench-stable scaffold integrates readily into bioactive molecule design, offering enhanced solubility and metabolic stability for medicinal chemistry applications.

Application

4-Bromo-5-methyl-1H-pyrrolo[2,3-b]pyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its stable bromine handle and electron-rich heterocyclic core. The methyl group enhances solubility and modulates reactivity, while the pyrrolo[2,3-b]pyridine scaffold provides structural rigidity and favorable pharmacophoric properties. This compound exhibits excellent bench stability, simplifies purification, and functions reliably in standard synthetic workflows for constructing complex nitrogen-containing scaffolds.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   28.68
  • LogP   2.63382
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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