Fmoc-N-Me-Gln(Trt)-OH

Name: Fmoc-N-Me-Gln(Trt)-OH
Brand: ChemScene
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CAS No. 1632075-13-8
Cat. No. CS-0198971
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Description

Fmoc-N-Me-Gln(Trt)-OH features a trifluoromethyl-protected glutamine residue with a methylated amide nitrogen, enabling efficient incorporation into peptide chains. The Fmoc group facilitates orthogonal deprotection, while the Trt side chain protection ensures stability during synthesis. This derivative supports reliable N-terminal capping and side-chain integrity in solid-phase peptide synthesis workflows.

Application

Fmoc-N-Me-Gln(Trt)-OH serves as a key building block in peptide synthesis, enabling the incorporation of N-methylglutamine with orthogonal protection. The Fmoc group allows for base-labile removal during stepwise chain elongation, while the Trt-protected glutamine side chain ensures stability and selective deprotection under mild acidic conditions. This derivative exhibits excellent bench stability, facilitates efficient coupling reactions, and supports high-purity peptide assembly in solid-phase workflows.

General Information

CAS No. 1632075-13-8
Cat. No. CS-0198971
Purity ≥97%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₄₀H₃₆N₂O₅
Molecular Weight 624.72
Synonym(s) N-α-(9-Fluorenylmethoxycarbonyl)-N-α-methyl-N-ω-trityl-L-glutamine
SMILES CN([C@@H](CCC(=O)NC(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)C(O)=O)C(=O)OCC4C5=C(C=CC=C5)C6=C4C=CC=C6

Computational Chemistry Data

TPSA 95.94
LogP 7.209
H_Acceptors 4
H_Donors 2
Rotatable_Bonds 11

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Amide

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Life Science Amino Acids and their Derivatives Glutamine and derivatives

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

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Fmoc-N-Me-Gln(Trt)-OH

CAS No. 1632075-13-8

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