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CS-W001157 4
Total: USD 88.00

2,4-Dimethylbenzyl alcohol

  • CAS No. 16308-92-2

  • Cat. No. CS-0128392
  • Purity≥98%
  • MDL No.MFCD00004624

*For research and further manufacturing use only, not for direct human use.

2,4-Dimethylbenzyl alcohol|CS-0128392

Structure of 16308-92-2

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General Information

  • CAS No. 16308-92-2
  • Cat. No. CS-0128392
  • Purity ≥98%
  • MDL No. MFCD00004624
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₂O
  • Molecular Weight 136.19
  • Synonym(s) 2,4-Dimethylbenzenemethanol
  • SMILES CC1=CC=C(C(C)=C1)CO

Description

2,4-Dimethylbenzyl alcohol offers enhanced stability and solubility in organic media due to its methyl-substituted aromatic ring. This bench-stable compound integrates readily into synthetic routes requiring a hydroxymethyl handle, serving as a valuable intermediate in pharmaceutical and agrochemical development.

Application

2,4-Dimethylbenzyl alcohol serves as a versatile building block in synthetic organic chemistry, offering enhanced stability and solubility compared to unsubstituted analogs. Its benzylic hydroxyl group enables straightforward derivatization—such as oxidation to the carboxylic acid or conversion to esters and ethers—while the electron-donating methyl groups stabilize adjacent intermediates. This compound functions effectively in pharmaceutical and agrochemical synthesis, particularly in the construction of aromatic scaffolds requiring steric bulk and tunable polarity.

Synthesis

  • Route1

    References

    • Takeda Pharmaceutical Company Limited Patent: EP1787991 A1, 2007 ; Location in patent: Page/Page column 45 ; EP 1787991 A1
  • Route2

    References

    • Neudeck Monatshefte fur Chemie, 1996 , vol. 127, # 2 p. 185 - 200
  • Route3

    References

    • Journal of Organic Chemistry, , vol. 26, p. 2310 - 2316

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   1.79574
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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