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CS-W001157 4
Total: USD 88.00

(4-Chloro-2-fluoro-6-methoxyphenyl)boronic acid

  • CAS No. 1628684-10-5

  • Cat. No. CS-0177284
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(4-Chloro-2-fluoro-6-methoxyphenyl)boronic acid|CS-0177284

Structure of 1628684-10-5

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General Information

  • CAS No. 1628684-10-5
  • Cat. No. CS-0177284
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇BClFO₃
  • Molecular Weight 204.39
  • Synonym(s) None
  • SMILES COC1=C(B(O)O)C(F)=CC(Cl)=C1

Description

This boronic acid features a chloro-fluoro-methoxy substitution pattern on the phenyl ring, delivering enhanced stability and compatibility in Suzuki-Miyaura cross-coupling reactions. The electron-deficient aryl moiety facilitates efficient coupling under standard conditions, while the methoxy group improves solubility and modulates reactivity.

Application

(4-Chloro-2-fluoro-6-methoxyphenyl)boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient construction of biaryl architectures. Its fluorinated and methoxy-substituted aryl framework provides enhanced metabolic stability and modulates electronic properties, making it valuable for medicinal chemistry and agrochemical synthesis. The boronic acid moiety offers good bench stability, mild reaction conditions, and compatibility with diverse functional groups, facilitating straightforward purification and scalability in synthetic workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   49.69
  • LogP   0.1675
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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