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CS-W001157 4
Total: USD 88.00

(4-Methylthiophen-2-yl)boronicacid

  • CAS No. 162607-15-0

  • Cat. No. CS-W020406
  • Purity≥97%
  • MDL No.MFCD01319040

*For research and further manufacturing use only, not for direct human use.

(4-Methylthiophen-2-yl)boronicacid|CS-W020406

Structure of 162607-15-0

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General Information

  • CAS No. 162607-15-0
  • Cat. No. CS-W020406
  • Purity ≥97%
  • MDL No. MFCD01319040
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₇BO₂S
  • Molecular Weight 141.98
  • Synonym(s) 4-Methylthiophene-2-boronic acid
  • SMILES CC1=CSC(B(O)O)=C1

Description

This boronate moiety integrates readily into Suzuki-Miyaura cross-coupling reactions, delivering arylated products with high functional group tolerance. The methylthio substituent enhances stability and solubility under standard conditions, enabling efficient synthesis of complex heteroaromatic frameworks in medicinal chemistry and materials science applications.

Application

(4-Methylthiophen-2-yl)boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient C–C bond formation with aryl and vinyl halides. The boronic acid moiety exhibits good bench stability and moderate functional group tolerance, facilitating straightforward purification and integration into complex molecular architectures. Its thienyl scaffold provides a robust heterocyclic core relevant to pharmaceutical and agrochemical research.

Synthesis

  • Route1
    • null|null
      616-44-4
    • ~%
    • In-stock
      (4-Methylthiophen-2-yl)boronicacid|CS-W020406
      162607-15-0
    • In-stock
      3-Methylthiophene-2-boronic acid|CS-W001236
      177735-09-0

    References

    • Tetrahedron Letters, , vol. 48, # 46 p. 8242 - 8245
  • Route2
    • null|null
      616-44-4
    • ~2%
    • null|null
      959785-70-7
    • In-stock
      (4-Methylthiophen-2-yl)boronicacid|CS-W020406
      162607-15-0

    References

    • Tetrahedron Letters, , vol. 48, # 46 p. 8242 - 8245

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H315-H318-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   40.46
  • LogP   -0.26368
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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