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CS-W001157 4
Total: USD 88.00

3-Methoxy-4-(difluoromethoxy)benzaldehyde

  • CAS No. 162401-70-9

  • Cat. No. CS-W023076
  • Purity≥98%
  • MDL No.MFCD03412217

*For research and further manufacturing use only, not for direct human use.

3-Methoxy-4-(difluoromethoxy)benzaldehyde|CS-W023076

Structure of 162401-70-9

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General Information

  • CAS No. 162401-70-9
  • Cat. No. CS-W023076
  • Purity ≥98%
  • MDL No. MFCD03412217
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₈F₂O₃
  • Molecular Weight 202.16
  • Synonym(s) 4-Difluoromethoxy-3-Methoxy-Benzaldehyde
  • SMILES O=CC1=CC=C(OC(F)F)C(OC)=C1

Description

3-Methoxy-4-(difluoromethoxy)benzaldehyde features a benzaldehyde core substituted with a methoxy group at the meta position and a difluoromethoxy moiety at the para position. This electron-deficient aldehyde integrates readily into cross-coupling reactions and serves as a key intermediate in the synthesis of bioactive heterocycles and fluorinated aromatic compounds under standard conditions.

Application

3-Methoxy-4-(difluoromethoxy)benzaldehyde serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and functionalized aryl scaffolds. Its electron-donating methoxy group and strongly polar difluoromethoxy substituent enhance solubility and metabolic stability. The aldehyde functionality facilitates efficient coupling reactions, including reductive amination and imine formation, with excellent bench stability and straightforward purification.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   35.53
  • LogP   2.1091
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   4

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