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CS-W001157 4
Total: USD 88.00

7-Benzyloxy-4-chloro-6-methoxyquinazoline

  • CAS No. 162364-72-9

  • Cat. No. CS-B0926
  • Purity≥96%
  • MDL No.MFCD04115120

*For research and further manufacturing use only, not for direct human use.

7-Benzyloxy-4-chloro-6-methoxyquinazoline|CS-B0926

Structure of 162364-72-9

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General Information

  • CAS No. 162364-72-9
  • Cat. No. CS-B0926
  • Purity ≥96%
  • MDL No. MFCD04115120
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₆H₁₃ClN₂O₂
  • Molecular Weight 300.74
  • Synonym(s) 7-(Benzyloxy)-4-chloro-6-methoxyquinazoline
  • SMILES COC1=CC2=C(Cl)N=CN=C2C=C1OCC3=CC=CC=C3

Description

7-Benzyloxy-4-chloro-6-methoxyquinazoline features a benzyl ether at the 7-position and a methoxy group at the 6-position, providing enhanced solubility and stability. The electron-deficient quinazoline core supports efficient coupling reactions, while the para-chloro substitution enables selective functionalization in medicinal chemistry applications.

Application

7-Benzyloxy-4-chloro-6-methoxyquinazoline serves as a versatile building block for the synthesis of quinazoline-based pharmaceutical intermediates. The benzyloxy group provides orthogonal protection for phenolic functionalities, while the 4-chloro substituent enables palladium-catalyzed cross-coupling reactions. Its bench-stable nature and compatibility with standard functional group manipulations facilitate efficient access to complex heterocyclic scaffolds in medicinal chemistry campaigns.

Synthesis

  • Route1

    References

    • KIRIN BEER KABUSHIKI KAISHA Patent: EP1153920 A1, 2001 ;
  • Route2
    • null|null
      91203-74-6
    • ~%
    • In-stock
      7-Benzyloxy-4-chloro-6-methoxyquinazoline|CS-B0926
      162364-72-9

    References

    • Journal of Medicinal Chemistry, , vol. 46, # 23 p. 4910 - 4925
  • Route3
    • Benzyl 4-(benzyloxy)-5-methoxy-2-nitrobenzoate|CS-0657106
      205259-40-1
    • ~%
    • In-stock
      7-Benzyloxy-4-chloro-6-methoxyquinazoline|CS-B0926
      162364-72-9

    References

    • Journal of Medicinal Chemistry, , vol. 46, # 23 p. 4910 - 4925

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   44.24
  • LogP   3.8708
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   4

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