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CS-W001157 4
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4-Bromo-4'- tert-butyl-biphenyl

  • CAS No. 162258-89-1

  • Cat. No. CS-0168368
  • Purity≥97%
  • MDL No.MFCD01321141

*For research and further manufacturing use only, not for direct human use.

4-Bromo-4'- tert-butyl-biphenyl|CS-0168368

Structure of 162258-89-1

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General Information

  • CAS No. 162258-89-1
  • Cat. No. CS-0168368
  • Purity ≥97%
  • MDL No. MFCD01321141
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₆H₁₇Br
  • Molecular Weight 289.21
  • Synonym(s) 4-tert-Butyl-4'-Butylbiphenyl
  • SMILES CC(C1=CC=C(C2=CC=C(Br)C=C2)C=C1)(C)C

Description

4-Bromo-4'-tert-butyl-biphenyl is a sterically hindered aryl halide featuring a bulky tert-butyl group that enhances stability and solubility. This configuration facilitates efficient cross-coupling reactions under standard conditions, enabling reliable C–C bond formation in synthetic sequences.

Application

4-Bromo-4'-tert-butylbiphenyl serves as a versatile building block in cross-coupling chemistry, enabling efficient Suzuki and Stille reactions due to its stable aryl bromide functionality and steric protection from the ortho-tert-butyl group. The bulky substituent enhances solubility and reduces unwanted side reactions, facilitating purification and scalability in synthetic workflows.

Synthesis

  • Route1
    • null|null
      507-20-0
    • In-stock
      4-Bromobiphenyl|CS-D1553
      92-66-0
    • ~74%
    • In-stock
      4-Bromo-4'- tert-butyl-biphenyl|CS-0168368
      162258-89-1

    References

    • Murphy, Sean; Yang, Xiquiang; Schuster, Gary B. Journal of Organic Chemistry, 1995 , vol. 60, # 8 p. 2411 - 2422

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   0
  • LogP   5.4136
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   1

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