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CS-W001157 4
Total: USD 88.00

3-Bromo-4-fluoro-1H-pyrazole

  • CAS No. 1621526-49-5

  • Cat. No. CS-0184172
  • Molecule weight164.96
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-Bromo-4-fluoro-1H-pyrazole|CS-0184172

Structure of 1621526-49-5

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General Information

  • CAS No. 1621526-49-5
  • Cat. No. CS-0184172
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃H₂BrFN₂
  • Molecular Weight 164.96
  • Synonym(s) None
  • SMILES FC1=CNN=C1Br

Description

3-Bromo-4-fluoro-1H-pyrazole is a halogenated heterocycle featuring complementary electrophilic (bromine) and nucleophilic (fluorine) sites. This electron-deficient scaffold enables selective cross-coupling reactions and serves as a key building block in medicinal chemistry, particularly for constructing bioactive molecules with enhanced metabolic stability and target specificity.

Application

3-Bromo-4-fluoro-1H-pyrazole serves as a versatile building block for the synthesis of functionalized heterocycles, enabling palladium-catalyzed cross-coupling reactions with high regioselectivity. The bromo and fluoro substituents provide orthogonal reactivity for sequential derivatization, while the pyrazole core offers stability under standard reaction conditions. This compound facilitates efficient access to medicinally relevant scaffolds in drug discovery workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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Computational Chemistry Data

  • TPSA   28.68
  • LogP   1.3113
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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