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2-(2,6-Difluoro-3,5-dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

  • CAS No. 1614233-69-0

  • Cat. No. CS-0120605
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-(2,6-Difluoro-3,5-dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane|CS-0120605

Structure of 1614233-69-0

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General Information

  • CAS No. 1614233-69-0
  • Cat. No. CS-0120605
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₁₉BF₂O₄
  • Molecular Weight 300.11
  • Synonym(s) None
  • SMILES CC(C1(C)C)(OB(C(C(F)=C2OC)=C(C(OC)=C2)F)O1)C

Description

This boronate ester features a 2,6-difluoro-3,5-dimethoxyphenyl moiety integrated into a tetramethyl-substituted dioxaborolane framework. The electron-rich aryl group enhances reactivity in Suzuki-Miyaura couplings, while the sterically shielded boron center ensures stability under ambient conditions and tolerance to moisture.

Application

2-(2,6-Difluoro-3,5-dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane serves as a stable, bench-ready boron building block for Suzuki-Miyaura cross-coupling reactions. The difluorodimethoxyaryl moiety enables selective functionalization in complex molecule synthesis, with the tetramethyl-substituted dioxaborolane enhancing stability and facilitating purification. Its compatibility with diverse reaction conditions makes it a practical reagent for constructing biaryl scaffolds in medicinal chemistry and materials science applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H332
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

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Computational Chemistry Data

  • TPSA   36.92
  • LogP   2.2812
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   3

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