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Structure of 1609651-90-2
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Alkyne-PEG4-maleimide is a bifunctional conjugation reagent featuring a reactive maleimide group and a terminal alkyne for bioorthogonal coupling. This PEG4 spacer provides enhanced solubility and reduced steric hindrance, enabling efficient labeling of cysteine residues in proteins and peptides under physiological conditions.
Alkyne-PEG4-maleimide serves as a versatile bifunctional reagent for site-specific conjugation in bioconjugate chemistry. The alkyne moiety enables reliable copper-catalyzed azide-alkyne cycloaddition (CuAAC), while the maleimide group facilitates rapid, selective Michael addition with cysteine residues under physiological conditions. The PEG4 spacer provides enhanced solubility and reduced steric hindrance, improving reaction kinetics and conjugate stability. This reagent is well-suited for labeling proteins, peptides, and other biomolecules in drug discovery and diagnostic applications.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: