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2-Methyl-8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuro[2,3-b]pyridine

  • CAS No. 1609374-04-0

  • Cat. No. CS-0102886
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Methyl-8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuro[2,3-b]pyridine|CS-0102886

Structure of 1609374-04-0

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General Information

  • CAS No. 1609374-04-0
  • Cat. No. CS-0102886
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₈H₂₀BNO₃
  • Molecular Weight 309.17
  • Synonym(s) None
  • SMILES CC1(C)C(C)(C)OB(C2=C3C(C4=CC=C(C)N=C4O3)=CC=C2)O1

Description

This boronate-functionalized benzofuropyridine integrates readily into Suzuki-Miyaura coupling reactions under standard conditions, delivering complex heterocyclic architectures with high efficiency. The tetramethylboronate moiety ensures stability and compatibility with aqueous and protic solvents, enabling robust cross-coupling in diverse synthetic sequences.

Application

2-Methyl-8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuro[2,3-b]pyridine serves as a versatile Suzuki coupling building block, enabling efficient C–C bond formation under mild conditions. The boronate moiety exhibits excellent stability and functional group tolerance, facilitating the construction of complex heteroaromatic architectures. Its bench-stable nature and compatibility with standard cross-coupling protocols make it ideal for iterative synthesis in medicinal chemistry and materials science applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   44.49
  • LogP   3.58862
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   1

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