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CS-W001157 4
Total: USD 88.00

Tetrahydrofuran-2-yl acetate

  • CAS No. 1608-67-9

  • Cat. No. CS-0160246
  • Purity≥95%
  • MDL No.MFCD09907739

*For research and further manufacturing use only, not for direct human use.

Tetrahydrofuran-2-yl acetate|CS-0160246

Structure of 1608-67-9

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General Information

  • CAS No. 1608-67-9
  • Cat. No. CS-0160246
  • Purity ≥95%
  • MDL No. MFCD09907739
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₀O₃
  • Molecular Weight 130.14
  • Synonym(s) Tetrahydro-2-furyl acetate
  • SMILES CC(OC1OCCC1)=O

Description

Tetrahydrofuran-2-yl acetate serves as a stable, moisture-tolerant acetyl donor in synthetic transformations. This bench-stable ester integrates readily into complex molecule assembly, offering selective protection and activation under mild conditions. Its cyclic ether backbone enhances solubility and compatibility across organic and biopharmaceutical workflows.

Application

Tetrahydrofuran-2-yl acetate serves as a stable, bench-friendly acetyl protecting group for alcohols and amines, enabling selective protection in complex molecule synthesis. It functions as a versatile building block in the construction of heterocyclic scaffolds and bioactive intermediates, offering excellent compatibility with standard coupling and reduction protocols. Its clean deprotection under mild acidic or basic conditions facilitates efficient synthetic workflows.

Synthesis

  • Route1
    • null|null
      1191-99-7
    • null|null
      64-19-7
    • ~58%
    • In-stock
      Tetrahydrofuran-2-yl acetate|CS-0160246
      1608-67-9

    References

    • Dolman, Nigel P.; More, Julia C. A.; Alt, Andrew; Knauss, Jody L.; Troop, Helen M.; Bleakman, David; Collingridge, Graham L.; Jane, David E. Journal of Medicinal Chemistry, 2006 , vol. 49, # 8 p. 2579 - 2592
  • Route2
    • null|null
      110-63-4
    • null|null
      87413-09-0
    • ~91%
    • In-stock
      Tetrahydrofuran-2-yl acetate|CS-0160246
      1608-67-9

    References

    • Roels; Metz Synlett, 2001 , # 6 p. 789 - 790

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   35.53
  • LogP   0.686
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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