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Structure of 16075-42-6
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2-Amino-4-(trifluoromethyl)pyrimidine features a trifluoromethyl group that imparts enhanced electron-withdrawing character and metabolic stability, while the amino substituent enables direct functionalization in heterocyclic synthesis. This combination facilitates efficient incorporation into kinase inhibitors and bioactive scaffolds under standard conditions.
2-Amino-4-(trifluoromethyl)pyrimidine serves as a versatile building block in medicinal chemistry, enabling efficient access to pyrimidine-based scaffolds through nucleophilic substitution and transition-metal-catalyzed coupling reactions. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the amino functionality provides a handle for derivatization. The compound exhibits good bench stability and is compatible with standard purification methods, facilitating its use in multi-step syntheses of bioactive molecules.
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GHS Pictogram :
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GHS No : GHS06,GHS08,GHS09
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Signal Word : Danger
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UN#: 2811
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H300-H319-H334-H410
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Precautionary Statements : P261-P264-P270-P273-P280-P285-P330-P391-P405-P501
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Lot numbers can be found on the outside label of a product: