Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

1-Ethynyl-4-(trifluoromethoxy)benzene

  • CAS No. 160542-02-9

  • Cat. No. CS-0042925
  • Purity≥97%
  • MDL No.MFCD03094333

*For research and further manufacturing use only, not for direct human use.

1-Ethynyl-4-(trifluoromethoxy)benzene|CS-0042925

Structure of 160542-02-9

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 160542-02-9
  • Cat. No. CS-0042925
  • Purity ≥97%
  • MDL No. MFCD03094333
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₅F₃O
  • Molecular Weight None
  • Synonym(s) 4-(Trifluoromethoxy)phenylacetylene
  • SMILES FC(F)(F)OC1=CC=C(C=C1)C#C

Description

1-Ethynyl-4-(trifluoromethoxy)benzene features a terminal alkyne paired with a strongly electron-withdrawing trifluoromethoxy group, enabling efficient copper-catalyzed coupling reactions. The molecule exhibits excellent stability under standard conditions and delivers high functional group tolerance in synthetic workflows.

Application

1-Ethynyl-4-(trifluoromethoxy)benzene serves as a versatile building block in transition-metal-catalyzed coupling reactions, enabling efficient access to conjugated enynes and arylated scaffolds. The terminal alkyne functionality facilitates Sonogashira, Glaser, and related couplings with high chemoselectivity. The trifluoromethoxy group imparts enhanced metabolic stability and lipophilicity, making this compound valuable for medicinal chemistry and materials science applications requiring robust functional group tolerance and bench-stable reactivity.

Synthesis

  • Route1
    • Trimethyl((4-(trifluoromethoxy)phenyl)ethynyl)silane|CS-1221504
      239104-48-4
    • ~%
    • In-stock
      1-Ethynyl-4-(trifluoromethoxy)benzene|CS-0042925
      160542-02-9

    References

    • WO2008/133867 A1, ; Page/Page column 39 ;
  • Route2
    • null|null
      103962-05-6
    • ~%
    • In-stock
      1-Ethynyl-4-(trifluoromethoxy)benzene|CS-0042925
      160542-02-9

    References

    • WO2008/133867 A1, ;
  • Route3

    References

    • Canadian Journal of Chemistry, , vol. 73, # 2 p. 191 - 203

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS07
Signal Word : Danger
UN#: 1993
Class : 3
Packing Group : Ⅲ
Hazard Statements : H226-H315-H319-H335
Precautionary Statements : P210-P233-P240-P241-P242-P243-P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P370+P378-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   9.23
  • LogP   2.5665
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 1-Ethynyl-4-(trifluoromethoxy)benzene sigma1-Ethynyl-4-(trifluoromethoxy)benzene manufacturer1-Ethynyl-4-(trifluoromethoxy)benzene price1-Ethynyl-4-(trifluoromethoxy)benzene structure1-Ethynyl-4-(trifluoromethoxy)benzene SDSbuy 1-Ethynyl-4-(trifluoromethoxy)benzene1-Ethynyl-4-(trifluoromethoxy)benzene supplier1-Ethynyl-4-(trifluoromethoxy)benzene uses1-Ethynyl-4-(trifluoromethoxy)benzene molecular weightprice of 1-Ethynyl-4-(trifluoromethoxy)benzene1-Ethynyl-4-(trifluoromethoxy)benzene chemical name formula of 1-Ethynyl-4-(trifluoromethoxy)benzene
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label