MC-Val-Cit-PAB

Name: MC-Val-Cit-PAB
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 159857-80-4
Cat. No. CS-M2769
Purity≥98%
MDL No.MFCD26142966

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HazMat Fee

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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Structure of 159857-80-4

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General Information

CAS No. 159857-80-4
Cat. No. CS-M2769
Purity ≥98%
MDL No. MFCD26142966
Storage 4°C, sealed storage, away from moisture and light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₈H₄₀N₆O₇
Molecular Weight 572.65
Synonym(s) None
SMILES CC(C)[C@@H](C(N[C@@H](CCCNC(N)=O)C(NC1=CC=C(CO)C=C1)=O)=O)NC(CCCCCN2C(C=CC2=O)=O)=O

Description

MC-Val-Cit-PAB is a cleavable linker designed for antibody-drug conjugate (ADC) applications. This moiety integrates a valine-citrulline dipeptide spacer with a para-aminobenzoyl (PAB) group, enabling site-specific drug attachment and efficient intracellular release via protease-sensitive bond cleavage. The structure ensures stability in circulation while facilitating targeted payload delivery.

Application

MC-Val-Cit-PAB serves as a well-established linker module in antibody-drug conjugates, enabling site-specific payload attachment via cleavable ester bonds. Its Val-Cit dipeptide sequence ensures efficient intracellular release of the cytotoxic agent under lysosomal protease activity. The PAB (para-aminobenzoyl) moiety enhances conjugate stability and facilitates purification. This construct offers robust bench stability, predictable conjugation efficiency, and compatibility with standard NHS-ester coupling protocols in therapeutic development workflows.

Synthesis

Route1
- In-stock
  
  55750-63-5
- In-stock
  
  159857-79-1
- ~94%
- In-stock
  
  159857-80-4
References
- SEATTLE GENETICS, INC. Patent: WO2007/8848 A2, 2007 ; Location in patent: Page/Page column 108; 136; 137 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 200.03
LogP 0.6769
H_Acceptors 7
H_Donors 6
Rotatable_Bonds 17

Other Classifications

Life Science Linker Cleavable Linkers

Life Science Linker Peptide Linkers

Life Science ADC Related Compound Cleavable Linker

Life Science ADC Related Compound Peptide/Protease Linker

Building Blocks Skeleton Aliphatic heterocycle compounds Pyrroline compounds

Chemical Biology Pharmaceutical Development and Drug Discovery Research Bioconjugation Enzyme Cleavable Linkers (Cleave Motif)

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Enzyme Cleavable Linkers (Cleave Motif)

Chemical Biology PEGylation PEG Oligomers

Biochemistry Biochemicals and Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Biochemistry Biochemicals and Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Enzyme Cleavable Linkers (Cleave Motif)

Biochemistry Biochemicals and Reagents Bioconjugation Enzyme Cleavable Linkers (Cleave Motif)

Biochemistry Pharmaceutical Development and Drug Discovery Research Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Biochemistry Pharmaceutical Development and Drug Discovery Research Antibody-Drug Conjugates (ADC) Preparation Research Reagents Enzyme Cleavable Linkers (Cleave Motif)

Key Words

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MC-Val-Cit-PAB

CAS No. 159857-80-4

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