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(2S,3R)-3-Hydroxypyrrolidine-2-carboxylic acid hydrochloride

  • CAS No. 159830-97-4

  • Cat. No. CS-0184644
  • Molecule weight167.59
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(2S,3R)-3-Hydroxypyrrolidine-2-carboxylic acid hydrochloride|CS-0184644

Structure of 159830-97-4

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General Information

  • CAS No. 159830-97-4
  • Cat. No. CS-0184644
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₀ClNO₃
  • Molecular Weight 167.59
  • Synonym(s) None
  • SMILES O=C([C@H]1NCC[C@H]1O)O.[H]Cl

Description

This chiral pyrrolidine derivative features a hydroxyl group at C3 and a carboxylic acid at C2, stabilized as the hydrochloride salt. The stereochemistry at C2 and C3 enables precise integration into peptide mimetics and bioactive scaffolds. Bench-stable and moisture-tolerant, it serves as a key building block for medicinal chemistry campaigns targeting conformationally restricted ligands.

Application

(2S,3R)-3-Hydroxypyrrolidine-2-carboxylic acid hydrochloride serves as a stereochemically defined building block for bioactive heterocycles and peptidomimetics. Its constrained pyrrolidine core with orthogonal hydroxyl and carboxylic acid functionalities enables direct incorporation into complex scaffolds via standard amide coupling, glycosylation, or metal-catalyzed transformations. The hydrochloride salt enhances bench stability and simplifies purification, facilitating scalable synthesis in medicinal chemistry campaigns.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   69.56
  • LogP   -0.7844
  • H_Acceptors   3
  • H_Donors   3
  • Rotatable_Bonds   1

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