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CS-W001157 4
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[S(R)]-N-[(S)-[2-(Diphenylphosphino)phenyl]phenylmethyl]-2-methyl-2-propanesulfinamide

  • CAS No. 1595319-97-3

  • Cat. No. CS-0147156
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

[S(R)]-N-[(S)-[2-(Diphenylphosphino)phenyl]phenylmethyl]-2-methyl-2-propanesulfinamide|CS-0147156

Structure of 1595319-97-3

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General Information

  • CAS No. 1595319-97-3
  • Cat. No. CS-0147156
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₉H₃₀NOPS
  • Molecular Weight 471.59
  • Synonym(s) (R)-N-((S)-(2-(diphenylphosphanyl)phenyl)(phenyl)methyl)-2-methylpropane-2-sulfinamide phenyl)(phenyl)methyl)-2- methylpropane-2-sulfinamide
  • SMILES O=[S@@](C(C)(C)C)N[C@@H](C1=CC=CC=C1)C2=CC=CC=C2P(C3=CC=CC=C3)C4=CC=CC=C4

Description

This chiral sulfinamide features a stereogenic center at the sulfinyl carbon and combines a diphenylphosphinoaryl group with a bulky tert-butyl substituent. The scaffold enables asymmetric induction in transition metal-catalyzed reactions, delivering high enantioselectivity in C–H functionalization and cross-coupling processes.

Application

[S(R)]-N-[(S)-[2-(Diphenylphosphino)phenyl]phenylmethyl]-2-methyl-2-propanesulfinamide serves as a chiral auxiliary in asymmetric synthesis, enabling stereoselective transformations through its rigid, well-defined chiral environment. The sulfinamide moiety facilitates enantioselective α-alkylation and conjugate addition reactions, while the diphenylphosphino group provides orthogonal coordination for transition metal catalysis. Its bench-stable nature and compatibility with common purification methods make it a practical choice for complex molecule assembly.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H413
Precautionary Statements : P264-P273-P280-P302+P352-P362+P364-P501

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Computational Chemistry Data

  • TPSA   29.1
  • LogP   5.586
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   7

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