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CS-W001157 4
Total: USD 88.00

3-Bromocarbazole

  • CAS No. 1592-95-6

  • Cat. No. CS-W008617
  • Purity≥98%
  • MDL No.MFCD00222621

*For research and further manufacturing use only, not for direct human use.

3-Bromocarbazole|CS-W008617

Structure of 1592-95-6

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General Information

  • CAS No. 1592-95-6
  • Cat. No. CS-W008617
  • Purity ≥98%
  • MDL No. MFCD00222621
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₈BrN
  • Molecular Weight None
  • Synonym(s) None
  • SMILES BrC1=CC2=C(C=C1)NC3=C2C=CC=C3

Description

Boc-Val-Ala-OH is a cleavable ADC linker. The Val-Ala is effectively cleaved by lysosomal proteolytic enzymes while being highly stable in human plasma, making this a potent strategy in ADC linker design. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Synthesis

  • Route1
    • null|null
      86-74-8
    • ~10%
    • In-stock
      3-Bromocarbazole|CS-W008617
      1592-95-6

    References

    • Chen, Xiaoqi; Mihalic, Jeff; Fan, Pingchen; Liang, Lingming; Lindstrom, Michelle; Wong, Sylvia; Ye, Qiuping; Fu, Ying; Jaen, Juan; Chen, Jin-Long; Dai, Kang; Li, Leping Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 1 p. 363 - 366
  • Route2

    References

    • US2011/260138 A1, ;
  • Route3
    • In-stock
      (4-Bromophenyl)hydrazine hydrochloride|CS-W013083
      622-88-8
    • null|null
      108-94-1
    • ~70%
    • In-stock
      3-Bromocarbazole|CS-W008617
      1592-95-6

    References

    • Xiao, Fuhong; Liao, Yunfeng; Wu, Mingyue; Deng, Guo-Jun Green Chemistry, 2012 , vol. 14, # 12 p. 3277 - 3280

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   15.79
  • LogP   4.0836
  • H_Acceptors   0
  • H_Donors   1
  • Rotatable_Bonds   0

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