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CS-W001157 4
Total: USD 88.00

2-(2-Aminophenyl)propan-2-ol

  • CAS No. 15833-00-8

  • Cat. No. CS-0154621
  • Purity≥97%
  • MDL No.MFCD04117984

*For research and further manufacturing use only, not for direct human use.

2-(2-Aminophenyl)propan-2-ol|CS-0154621

Structure of 15833-00-8

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General Information

  • CAS No. 15833-00-8
  • Cat. No. CS-0154621
  • Purity ≥97%
  • MDL No. MFCD04117984
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₃NO
  • Molecular Weight 151.21
  • Synonym(s) o-aminophenyl-dimethylcarbinol
  • SMILES CC(C)(C1=CC=CC=C1N)O

Description

This bench-stable, moisture-tolerant compound features a phenolic hydroxyl group flanked by an ortho-aminomethyl substituent, enabling direct incorporation into bioactive scaffolds. The rigid tertiary alcohol framework supports efficient functionalization in synthetic and medicinal chemistry workflows.

Application

2-(2-Aminophenyl)propan-2-ol serves as a versatile building block in medicinal chemistry, enabling the construction of biologically relevant heterocyclic scaffolds. Its tertiary alcohol functionality offers enhanced bench stability and facilitates efficient derivatization via direct functionalization or coupling reactions. The ortho-aminophenyl group provides a handle for cyclization and metal-catalyzed transformations, supporting the synthesis of fused ring systems commonly found in kinase inhibitors and other therapeutic agents.

Synthesis

  • Route1
    • null|null
      75-16-1
    • null|null
      134-20-3
    • ~95%
    • In-stock
      2-(2-Aminophenyl)propan-2-ol|CS-0154621
      15833-00-8

    References

    • Bowman, W. Russell; Fletcher, Anthony J.; Pedersen, Jan M.; Lovell, Peter J.; Elsegood, Mark R.J.; Hernandez Lopez, Elena; McKee, Vickie; Potts, Graeme B.S. Tetrahedron, 2007 , vol. 63, # 1 p. 191 - 203
  • Route2
    • null|null
      134-20-3
    • null|null
      74-88-4
    • ~%
    • In-stock
      2-(2-Aminophenyl)propan-2-ol|CS-0154621
      15833-00-8

    References

    • Chevron Research Company Patent: US4030906 A1, 1977 ;
  • Route3
    • null|null
      917-64-6
    • 2'-Aminoacetophenone Linagliptin Impurity|CS-0229112
      551-93-9
    • ~90%
    • In-stock
      2-(2-Aminophenyl)propan-2-ol|CS-0154621
      15833-00-8

    References

    • Yao, Sheng; Gallenkamp, Daniel; Woelfel, Katharina; Lueke, Bettina; Schindler, Michael; Scherkenbeck, Juergen Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 15 p. 4669 - 4678

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   46.25
  • LogP   1.4962
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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