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CS-W001157 4
Total: USD 88.00

tert-Butyl 4-(aminomethyl)-4-phenylpiperidine-1-carboxylate

  • CAS No. 158144-82-2

  • Cat. No. CS-0048253
  • Molecule weight290.40
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 4-(aminomethyl)-4-phenylpiperidine-1-carboxylate|CS-0048253

Structure of 158144-82-2

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General Information

  • CAS No. 158144-82-2
  • Cat. No. CS-0048253
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₇H₂₆N₂O₂
  • Molecular Weight 290.40
  • Synonym(s) 1-N-BOC-4-AMINOMETHYL-4-PHENYLPIPERIDINE
  • SMILES CC(C)(C)OC(=O)N1CCC(CN)(CC1)C1=CC=CC=C1

Synthesis

  • Route1
    • Tert-butyl 4-cyano-4-phenylpiperidine-1-carboxylate|CS-0272817
      158144-79-7
    • ~82%
    • tert-Butyl 4-(aminomethyl)-4-phenylpiperidine-1-carboxylate|CS-0048253
      158144-82-2

    References

    • Stevenson, Graeme I.; Huscroft, Ian; MacLeod, Angus M.; Swain, Christopher J.; Cascieri, Margaret A.; Chicchi, Gary G.; Graham, Michael I.; Harrison, Timothy; Kelleher, Fintan J.; Kurtz, Marc; Ladduwahetty, Tamara; Merchant, Kevin J.; Metzger, Joseph M.; MacIntyre; Sadowski, Sharon; Sohal, Balbinder; Owens, Andrew P. Journal of Medicinal Chemistry, 1998 , vol. 41, # 23 p. 4623 - 4635
  • Route2

    References

    • Elliott; Broughton; Cascieri; Chicchi; Huscroft; Kurtz; MacLeod; Sadowski; Stevenson Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 14 p. 1851 - 1856
  • Route3

    References

    • Dinnell, Kevin; Elliott, Jason Matthew; Hollingworth, Gregory John; Ridgill, Mark Peter; Shaw, Duncan Edward Patent: US2001/39286 A1, 2001 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07,GHS09
Signal Word : Warning
UN#: 3077
Class : 9
Packing Group : Ⅲ
Hazard Statements : H302-H315-H317-H319-H410
Precautionary Statements : P261-P264-P270-P272-P273-P280-P302+P352-P330-P362+P364-P391-P501

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Computational Chemistry Data

  • TPSA   55.56
  • LogP   2.914
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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