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Structure of 15813-07-7
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5-Iodo-4-methyl-1H-imidazole is a bench-stable, electron-deficient imidazole derivative featuring a reactive iodine at the 5-position and a methyl group at the 4-position. This combination enables direct functionalization in cross-coupling reactions and facilitates incorporation into bioactive scaffolds. The molecule's polarity and stability under standard conditions support reliable handling in synthetic workflows.
5-Iodo-4-methyl-1H-imidazole serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions for the synthesis of functionalized imidazoles. The iodide group provides high reactivity in Suzuki, Stille, and Negishi couplings, while the methyl substituent enhances stability and modulates electronic properties. This compound exhibits excellent bench stability and facilitates straightforward purification, making it well-suited for iterative library synthesis and API intermediate development.
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: