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CS-W001157 4
Total: USD 88.00

5-Iodopyrimidine-2,4-diamine

  • CAS No. 157924-46-4

  • Cat. No. CS-0045778
  • Purity≥97%
  • MDL No.MFCD22570516

*For research and further manufacturing use only, not for direct human use.

5-Iodopyrimidine-2,4-diamine|CS-0045778

Structure of 157924-46-4

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General Information

  • CAS No. 157924-46-4
  • Cat. No. CS-0045778
  • Purity ≥97%
  • MDL No. MFCD22570516
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₅IN₄
  • Molecular Weight 236.01
  • Synonym(s) 5-Iodo-2,4-pyrimidinediamine
  • SMILES NC1=NC=C(I)C(N)=N1

Description

5-Iodopyrimidine-2,4-diamine serves as a key scaffold for constructing functionalized pyrimidine derivatives. The iodine substituent enables efficient cross-coupling reactions, while the diamine functionality provides dual sites for conjugation. This compound integrates readily into bioactive molecule synthesis under standard conditions.

Application

5-Iodopyrimidine-2,4-diamine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions for the construction of biologically relevant pyrimidine scaffolds. The iodide group facilitates efficient Suzuki, Stille, and Negishi couplings, while the diamino functionality provides sites for derivatization or metal coordination. Its bench-stable nature and compatibility with diverse reaction conditions make it suitable for iterative synthesis and library generation.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   77.82
  • LogP   0.2456
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   0

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