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Structure of 15777-70-5
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4-Hydroxy-3-methylbenzonitrile features a phenolic hydroxyl group and a nitrile functionality positioned ortho to each other on a methyl-substituted benzene ring. This arrangement enables dual reactivity, supporting coupling reactions and serving as a key scaffold in bioactive molecule synthesis. The compound exhibits enhanced solubility in organic solvents and stability under standard bench conditions.
4-Hydroxy-3-methylbenzonitrile serves as a versatile building block in medicinal chemistry, enabling direct access to substituted phenolic scaffolds through standard coupling and functional group interconversion. Its ortho-hydroxynitrile motif provides compatibility with palladium-catalyzed cross-coupling, nucleophilic substitution, and electrophilic aromatic substitution reactions. The molecule exhibits bench stability, facilitates straightforward purification, and functions as a key intermediate in the synthesis of bioactive heterocycles and API precursors.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: