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Di-1H-pyrrol-2-ylmethanone

  • CAS No. 15770-21-5

  • Cat. No. CS-0136212
  • Purity≥97%
  • MDL No.MFCD01686800

*For research and further manufacturing use only, not for direct human use.

Di-1H-pyrrol-2-ylmethanone|CS-0136212

Structure of 15770-21-5

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General Information

  • CAS No. 15770-21-5
  • Cat. No. CS-0136212
  • Purity ≥97%
  • MDL No. MFCD01686800
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₈N₂O
  • Molecular Weight None
  • Synonym(s) di(1H-pyrrol-2-yl)methanone
  • SMILES O=C(C1=CC=CN1)C2=CC=CN2

Description

Di-1H-pyrrol-2-ylmethanone features a dual pyrrole scaffold linked via a carbonyl group, delivering enhanced electron density and structural rigidity. This configuration supports stable integration into conjugated systems, enabling efficient coupling in synthetic routes requiring robust heterocyclic platforms.

Application

Di-1H-pyrrol-2-ylmethanone serves as a versatile dihydropyrrole-based building block for heterocyclic synthesis, enabling efficient access to substituted pyrroloindole and fused polycyclic scaffolds. Its electrophilic carbonyl group facilitates nucleophilic addition reactions with amines and thiols under mild conditions, offering high functional group tolerance and excellent bench stability. The molecule functions effectively in solid-phase and solution-phase workflows, supporting scalable synthesis of complex molecular architectures relevant to medicinal chemistry campaigns.

Synthesis

  • Route1
    • null|null
      21401-55-8
    • ~84%
    • In-stock
      Di-1H-pyrrol-2-ylmethanone|CS-0136212
      15770-21-5

    References

    • Groot, J. A. de; Steen, R. van der; Fokkens, R.; Lugtenburg, J. Recueil: Journal of the Royal Netherlands Chemical Society, 1982 , vol. 101, # 1 p. 35 - 40
  • Route2

    References

    • Katritzky, Alan R.; Suzuki, Kazuyuki; Singh, Sandeep K.; He, Hai-Ying Journal of Organic Chemistry, 2003 , vol. 68, # 14 p. 5720 - 5723
  • Route3
    • null|null
      75-44-5
    • ~%
    • In-stock
      Di-1H-pyrrol-2-ylmethanone|CS-0136212
      15770-21-5

    References

    • Hess; Anselm Chemische Berichte, 1921 , vol. 54, p. 2325

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   48.65
  • LogP   1.5738
  • H_Acceptors   1
  • H_Donors   2
  • Rotatable_Bonds   2

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