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CS-W001157 4
Total: USD 88.00

3-Methylenecyclobutanecarboxylic acid

  • CAS No. 15760-36-8

  • Cat. No. CS-M1233
  • Purity≥98%
  • MDL No.MFCD00101901

*For research and further manufacturing use only, not for direct human use.

3-Methylenecyclobutanecarboxylic acid|CS-M1233

Structure of 15760-36-8

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General Information

  • CAS No. 15760-36-8
  • Cat. No. CS-M1233
  • Purity ≥98%
  • MDL No. MFCD00101901
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₈O₂
  • Molecular Weight 112.13
  • Synonym(s) Cyclobutanecarboxylic acid, 3-Methylene-
  • SMILES C=C1CC(C(O)=O)C1

Description

This strained-ring carboxylic acid integrates a reactive methylene group adjacent to a cyclobutane core, enabling direct functionalization in synthetic sequences. The inherent ring strain drives selective transformations, while the carboxylate moiety provides a handle for derivatization under mild conditions.

Application

3-Methylenecyclobutanecarboxylic acid serves as a versatile building block for strained ring systems and functionalized cyclobutane scaffolds. Its conjugated olefin and carboxylic acid groups enable diverse transformations, including Michael additions, hydrogenations, and coupling reactions. The molecule exhibits bench stability and facilitates efficient synthesis of bioactive intermediates and heterocyclic frameworks through established methodologies.

Synthesis

  • Route1

    References

    • US2013/79324 A1, ; Paragraph 0934; 0935 ; US 20130079324 A1
  • Route2
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      463-49-0
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      79-10-7
    • ~%
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      92723-44-9
    • In-stock
      3-Methylenecyclobutanecarboxylic acid|CS-M1233
      15760-36-8

    References

    • Journal of the American Chemical Society, , vol. 81, p. 2723,2725
  • Route3
    • null|null
      463-49-0
    • null|null
      79-10-7
    • ~%
    • In-stock
      3-Methylenecyclobutanecarboxylic acid|CS-M1233
      15760-36-8

    References

    • Journal of the American Chemical Society, , vol. 81, p. 2723,2725

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H318-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   1.0372
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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