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2-Amino-2-(4-methylphenyl)ethan-1-ol

  • CAS No. 157142-48-8

  • Cat. No. CS-0153074
  • Purity≥97%
  • MDL No.MFCD08277197

*For research and further manufacturing use only, not for direct human use.

2-Amino-2-(4-methylphenyl)ethan-1-ol|CS-0153074

Structure of 157142-48-8

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General Information

  • CAS No. 157142-48-8
  • Cat. No. CS-0153074
  • Purity ≥97%
  • MDL No. MFCD08277197
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₃NO
  • Molecular Weight 151.21
  • Synonym(s) 2-Amino-2-(4-methylphenyl)ethanol
  • SMILES CC1=CC=C(C=C1)C(CO)N

Description

2-Amino-2-(4-methylphenyl)ethan-1-ol features a benzylamine scaffold with a para-methyl substituent, delivering enhanced solubility and stability under standard conditions. This bench-stable, moisture-tolerant compound integrates readily into synthetic sequences requiring polar, electron-rich aryl-aliphatic linkages.

Application

2-Amino-2-(4-methylphenyl)ethan-1-ol serves as a versatile building block in medicinal chemistry, enabling the synthesis of β-amino alcohol scaffolds through standard reduction or condensation protocols. Its benzylic amine and hydroxyl groups exhibit excellent functional group tolerance, facilitating downstream derivatization. The compound demonstrates good bench stability and ease of purification, making it well-suited for iterative synthesis workflows in API development.

Synthesis

  • Route1

    References

    • Jnoff, Eric; Albrecht, Claudia; Barker, John J.; Barker, Oliver; Beaumont, Edward; Bromidge, Steven; Brookfield, Frederick; Brooks, Mark; Bubert, Christian; Ceska, Tom; Corden, Vincent; Dawson, Graham; Duclos, Stephanie; Fryatt, Tara; Genicot, Christophe; Jigorel, Emilie; Kwong, Jason; Maghames, Rosemary; Mushi, Innocent; Pike, Richard; Sands, Zara A.; Smith, Myron A.; Stimson, Christopher C.; Courade, Jean-Philippe ChemMedChem, 2014 , vol. 9, # 4 p. 699 - 705
  • Route2
    • null|null
      622-97-9
    • ~%
    • In-stock
      2-Amino-2-(4-methylphenyl)ethan-1-ol|CS-0153074
      157142-48-8

    References

    • Barlow, Thomas; Dipple, Anthony Chemical Research in Toxicology, 1998 , vol. 11, # 1 p. 44 - 53
  • Route3
    • null|null
      144924-04-9
    • ~%
    • In-stock
      2-Amino-2-(4-methylphenyl)ethan-1-ol|CS-0153074
      157142-48-8

    References

    • Barlow, Thomas; Dipple, Anthony Chemical Research in Toxicology, 1998 , vol. 11, # 1 p. 44 - 53

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362

Quality Control

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Computational Chemistry Data

  • TPSA   46.25
  • LogP   0.98712
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   2

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