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CS-W001157 4
Total: USD 88.00

2-Fluoro-4-methoxy-5-nitroaniline

  • CAS No. 1569986-91-9

  • Cat. No. CS-0144024
  • Molecule weight186.14
  • Purity≥98%
  • MDL No.MFCD29053562

*For research and further manufacturing use only, not for direct human use.

2-Fluoro-4-methoxy-5-nitroaniline|CS-0144024

Structure of 1569986-91-9

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General Information

  • CAS No. 1569986-91-9
  • Cat. No. CS-0144024
  • Purity ≥98%
  • MDL No. MFCD29053562
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇FN₂O₃
  • Molecular Weight 186.14
  • Synonym(s) None
  • SMILES NC1=CC([N+]([O-])=O)=C(OC)C=C1F

Description

2-Fluoro-4-methoxy-5-nitroaniline features a trifunctional aromatic core with electron-withdrawing nitro and fluoro groups paired with an electron-donating methoxy group. This strategic electronic balance enables selective coupling in cross-coupling reactions and facilitates access to advanced intermediates for pharmaceutical and agrochemical development under standard conditions.

Application

2-Fluoro-4-methoxy-5-nitroaniline serves as a versatile building block in medicinal chemistry, enabling the synthesis of fluorinated heterocycles and bioactive scaffolds. Its orthogonal functional groups—fluorine, methoxy, and nitro—facilitate sequential transformations under standard conditions. The compound exhibits good bench stability and is compatible with palladium-catalyzed couplings, nucleophilic substitutions, and reduction protocols, making it well-suited for modular synthesis workflows in API development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H311-H331
Precautionary Statements : P261-P264-P270-P280-P302+P352-P304+P340-P330-P361-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   78.39
  • LogP   1.3247
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   2

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