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CS-W001157 4
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3-Bromo-2-fluorophenol

  • CAS No. 156682-53-0

  • Cat. No. CS-W006424
  • Purity≥95%
  • MDL No.MFCD09864673

*For research and further manufacturing use only, not for direct human use.

3-Bromo-2-fluorophenol|CS-W006424

Structure of 156682-53-0

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General Information

  • CAS No. 156682-53-0
  • Cat. No. CS-W006424
  • Purity ≥95%
  • MDL No. MFCD09864673
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄BrFO
  • Molecular Weight 191.00
  • Synonym(s) 3-Bromo-2-Fluoro-Phenol
  • SMILES OC1=C(F)C(Br)=CC=C1

Description

3-Bromo-2-fluorophenol features a strategically positioned bromine and fluorine substituent on the aromatic ring, enabling selective functionalization in cross-coupling reactions. This electron-deficient phenolic scaffold integrates readily into complex molecular architectures under standard conditions.

Application

3-Bromo-2-fluorophenol serves as a valuable building block in medicinal chemistry and agrochemical synthesis, enabling direct incorporation of bromo and fluoro substituents for subsequent cross-coupling or electrophilic functionalization. Its bench-stable nature and compatibility with palladium-catalyzed reactions facilitate efficient access to complex aryl scaffolds. The ortho-fluoro substitution enhances metabolic stability in target molecules, while the bromo group provides a reliable handle for diversification via Suzuki, Stille, or Negishi coupling protocols.

Synthesis

  • Route1

    References

    • Synlett, , # 4 p. 633 - 637

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   2.2938
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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