N,3-Dimethylpyridin-2-amine

Name: N,3-Dimethylpyridin-2-amine
Brand: ChemScene
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CAS No. 156267-13-9
Cat. No. CS-0238113
Purity≥98%
MDL No.MFCD16697578

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General Information

CAS No. 156267-13-9
Cat. No. CS-0238113
Purity ≥98%
MDL No. MFCD16697578
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₁₀N₂
Molecular Weight 122.17
Synonym(s) 2-Pyridinamine,N,3-dimethyl-(9CI)
SMILES CC1=CC=CN=C1NC

Description

N,3-Dimethylpyridin-2-amine features a pyridine core with methyl groups at the nitrogen and meta positions, creating a sterically hindered, electron-rich heterocyclic scaffold. This configuration enhances nucleophilicity and stability under standard conditions, enabling efficient coupling in transition-metal catalysis. The compound serves as a robust ligand in palladium-catalyzed cross-coupling reactions, where its steric and electronic profile promotes catalyst turnover and functional group tolerance.

Application

N,3-Dimethylpyridin-2-amine serves as a versatile building block in medicinal chemistry and catalysis, offering enhanced solubility and tunable basicity due to its N-methylated pyridine core. The 3-methyl group provides steric protection and stabilizes the nitrogen lone pair, enabling reliable participation in Pd-catalyzed cross-coupling reactions. Its bench-stable nature and compatibility with diverse functional groups make it ideal for constructing complex heterocyclic scaffolds in API development workflows.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

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Computational Chemistry Data

TPSA 24.92
LogP 1.43172
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

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N,3-Dimethylpyridin-2-amine

CAS No. 156267-13-9

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